Nausicalm Should Not Be Given To Individuals With Known Hypersensitivity To Cyclizine. As With Other Anticholinergic Agents, Cyclizine Should Be Used With Caution And Appropriate Monitoring In Patients With Glaucoma, Obstructive Disease Of The Gastrointestinal Tract And In Males With Possible Prostatic Hypertrophy. Cyclizine Should Be Used With Caution In Patients With Severe Heart Failure. In Such Patients, Cyclizine May Cause A Fall In Cardiac Output Associated With Increases In Heart Rate, Mean Arterial Pressure And Pulmonary Wedge Pressure. There Have Been No Specific Studies In Hepatic And/Or Renal Dysfunction. There Is No Experience Of The Effect Of Cyclizine On Human Fertility. In The Absence Of Any Definitive Human Data, The Use Of Cyclizine In Pregancy Is Not Advised. It Is Not Known Whether Cyclizine Or Its Metabolites Are Excreted In Human Milk. Effects Of The Ability To Drive And Use Machines Studies Designed To Detect Drowsiness Did Not Reveal Sedation In Healthy Adults Who Took A Single Oral Therapeuticdose (50Mg) Of Cyclizine. Patients Should Not Drive Or Operate Machinery Until They Have Determined Their Own Response.